Patient characteristics and p16 expression. We detected p16 expression in 72 of 662 (10.9%) tissues of patients with HNSCC. An example of p16 positive case was shown in the Fig. 1a. Most patients were males and smokers presented with stage IVa/b disease (Table 1).The baseline characteristics of p16-positive and p16-negative patients were comparable, except for the site of primary tumor
The mean (SD) of TIS values was, respectively, 10.90 (2.08), 10.87 (2.37) and 9.92 (3.30) for claudin-4, MOC-31 and p16. the authors also concluded that patients with strongly p16-positive cancers had a 2.5-fold increased risk of death and more than three-fold increased risk of disease recurrence as compared with those with p16-negative
Endometrial carcinomas are heterogeneous tumors that require accurate diagnosis and classification. This article reviews the current criteria and challenges for interpreting p53 immunohistochemistry in endometrial carcinomas, and proposes a practical algorithm to improve reproducibility and clinical utility. Learn more about the role of p53 in endometrial carcinogenesis and prognosis.
In addition to liquid-based cytology (LBC) and HR HPV testing, p16/ki-67 dual-staining is another method for cervical cancer screening. The combination of any two methods can improve the accuracy of screening, but some cervical lesions are still missed or misdiagnosed. In this retrospective study, the significance of LBC, HR HPV testing and especially p16/ki-67 dual-staining in cervical lesion
CDKN2A is a tumor suppressor gene located on chromosome 9p21 that encodes the cell cycle inhibitor protein p16 [].Genetic alterations of this gene are frequently observed in various types of human cancers [1-3].With regard to brain tumors and prognosis, homozygous deletion of the CDKN2A gene has been reported to be associated with shortened survival in isocitrate dehydrogenase (IDH)-mutant
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what does p16 positive mean
